Paracetamol (Acetaminophen) hepatotoxicity and its management. NAPQI Wikipedia GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY File:Paracetamol metabolism (de).png Wikimedia Commons Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite Liver injury induced by paracetamol and challenges associated with intentional and unintentional use