Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Napqi hi res stock photography and images Alamy Biotransformation, Elimination and Bile Acid Metabolism Abdominal Key