Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Acetaminophen Anesthesia Key USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog Acetaminophen Depletes Glutathione Essential Formulas Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Glutathione Invigor Medical