The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications A new class of drugs called senolytics works by hunting down and destroying senescent "zombie cells" that accumulate with age and drive wrinkles, weak bones, and organ decline. In an early human Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway FOX04 DRI 10 mg Particle Peptides Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv Directly from the paper covered by the post earlier, 90 year old equivalent mouse before and after treatment with FOXO4 D reverso inversio peptide, a FOXO4 inhibitor that blocks FOXO4 from arresting senescent cell apoptosis.